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Saturday, May 29, 2004

Damn lies, Guardian Lies, and Statistics (Off Topic) 
The Guardian's Polly Toynbee has a theory that 1.) The US is the most unequal society in the world, while the Scandinavians had the most equal; 2.) That the US is the most obese society in the world, while the Scandinavians are the least obese society in the world, and that 3.) It follows that inequality must cause obesity. Simply increase the levels of equality in the US, and we'll lose weight like magic.

Point number 3 is logically fallacious on its face. Correlation does not demonstrate causality.

But she's even dead wrong about the correlations, as the Daily Ablution convincingly points out.

Splash, out

Jason

Comments:
Everyone has a method of reducing the obesity rate. Especially those who are not fat. Whoopee.

Well, almost everyone: after the silly BMI (Marilyn Monroe was seriously underweight? Michael Jordan was teetering between obesity and morbid obesity?) was adopted it was decided it was not scary enough, so it was "adjusted" and roughly 20 million US citizens went from "normal" to "obese" without gaining an ounce...

Now, I consider myself fat-to-obese. And I keep reading medical weblogs, occasionally seeing posts about it. And my own "primary physician" is actually a medical clinic at a teaching hospital, so when the interns/residents turn over each year I get the start of the weight lecture.

Why just "the start" of the lecture? Because I interrupt and tell them -
^ A few years ago I was hospitalized for two weeks. During
^ that time I ate the same hospital food as everyone else,
^ and of course the same portions. I got the same amount of
^ exercise - a bit more than I normally do.
^
^ I gained twelve pounds in those two weeks.
^
^ If you aren't prepared to offer a believable reason for
^ that, I cannot accept anything you say except that cutting
^ down to 1200 calories per day and walking five miles per
^ day would cause a weight loss. It would also kill me, but
^ does that bother you?
I've never had anyone attempt the lecture a second time.

Changing diet and exercise will help most (well, those who can stand it) people. Note, though, it has to be a permanent change: lose-gain-lose-gain cycling is FAR more unhealthy than being overweight, up to the "morbidly" obese point.

Once you have a certain percentage of fat, it is like a cancer, if somewhat easier to treat. Indeed, one study found that some cancer-indicators in the blood also applied to fat buildup, and some cancer treatments (the ones that attack the cancer by recognizing the blood change and cutting off flow to capillaries with large concentrations of the changed blood chemistry) were effective in controlling weight: not conclusive as yet, a lot of research needs to be done, but if borne out offers hope. -

http://www.reuters.com/newsArticle.jhtml;jsessionid=KIBCCNTVLXBUMCRBAE0CFEY?type=scienceNews&storyID=5082664
Study: Molecule 'Vacuums Up' Fat from Mice
A new approach being used to fight cancer may also help fight fat, U.S. researchers said on Sunday. ... When fat mice were injected with the new "fat-zapper" every day for a month, they all slimmed down to normal weight with no visible side-effects, the researchers reported in the June [2004] issue of Nature Medicine. ... In cancer, a new class of drugs called angiogenesis inhibitors starve tumors by cutting off their blood supply.
Arap and colleagues have turned this approach against fat.
It makes sense, Arap argues -- fat cells grow and proliferate quickly just as cancer cells do. Like tumors, they build themselves a scaffold of tiny blood vessels called capillaries for sustenance.
Cancer drugs tackle different proteins involved in building blood vessels. Arap's team looked for a protein that might be found only in the blood vessels that feed fat cells.
They found one. Prohibitin is active on the surface of fat-feeding blood vessels. They also found a monoclonal antibody -- a synthetic immune system molecule -- that finds and attaches to prohibitin alone.
...they put normal mice on what they called a "cafeteria diet." "It is high in calories," Arap said in a telephone interview. The mice started out weighing just under an ounce, 20 to 25 grams, but more than doubled their weight on the diet.
Then they injected half the mice with the new fat-killing molecule. After daily injections for a month, the fat mice lost, on average, 30 percent of their body weight.
"The weight loss was also accompanied by a reversal of fatty liver and glucose intolerance," Arap said, describing two common complications of obesity. "They actually looked better."
 
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